Cytostatic and Antibacterial Activity of Some Compounds Isolated from Several Lamiaceae Species from the Canary Islands

Abstract

A chemotherapeutic study has been carried out on thirteen products Eeleven diterpenes, one lignan, (+)-sesamin, and a coumarin, siderin] isolated from Salvia and Sideritis species considered endemic to the Canarian flora. The data obtained suggest that some diterpenoid compounds show an interesting cytostatic activity, specially galdosol (6) with an ID₅₀ value of 0.5 µg/ml. These compounds also evidence a moderate antibacterial activity against Gram positive bacteria.

Salvia - Sideritis - Lamiaceae - cytostatic activity - antibacterial activity