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Planta Med 1990; 56(4): 339-352
DOI: 10.1055/s-2006-960979
Review

© Georg Thieme Verlag Stuttgart · New York

Recent Developments in the Biosynthesis of the Tropane Alkaloids1

Edward Leete
  • Natural Products Laboratory, Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, U.S.A.
1 Presented in part at the 37th Annual Congress of the Gesellschaft für Arzneipflanzenforschung, September 5-9, 1989, Braunschweig, FRG
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Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

Recent work on the biosynthesis of the tropane moiety of cocaine, hyoscamine, scopolamine, and related alkaloids is reviewed. Revision of the generally accepted biosynthetic pathway to these alkaloids is now proposed in the light of new discoveries. New information on the biosynthesis of some of the acid moieties (benzoic, tiglic and tropic acid) of the tropane ester alkaloids is also discussed.

Key words

Biosynthesis - tropane alkaloids - cocaine - hyoscyamine - scopolamine - tropane ester alkaloids