Effect of Salvianolic Acid A, a Depside from Roots of Salvia miltiorrhiza, on Gastric H+, K+-ATPase

Shigeru Murakami; Haruko Kijima; Yoshihiko Isobe; Makoto Muramatsu; Hironaka Aihara; Susumu Otomo; Li Liang-niang; Ai Chun-bo

doi:10.1055/s-2006-960982

Planta Med 1990; 56(4): 360-363
DOI: 10.1055/s-2006-960982

Papers

Effect of Salvianolic Acid A, a Depside from Roots of Salvia miltiorrhiza, on Gastric H+, K+-ATPase

Shigeru Murakami¹ , Haruko Kijima¹ , Yoshihiko Isobe¹ , Makoto Muramatsu¹ , Hironaka Aihara¹ , Susumu Otomo¹ , Li Liang-niang² , Ai Chun-bo²

¹Research Center, Taisho Pharmaceutical Co. Ltd., Ohmiya, Saitama 330, Japan
²Institute of Materia Medica, Chinese Academy of Medical Science, Beijing 100050, People's Republic of China

Abstract

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Abstract

Salvianolic acid A, a depside from the roots of Salvia miltiorrhiza, inhibited pig gastric H⁺,K⁺-ATPase and pNPPase with 50% inhibition values (IC₅₀) of 5.2 × 10^-7 M and 1.7 × 10^-6 M, respectively. Kinetic studies revealed that the inhibition patterns induced by Salvianolic acid A were competitive with respect to ATP and noncompetitive with respect to K⁺. Salvianolic acid A (25 mg/kg, i.p.) significantly inhibited acid secretion in pylorus-ligated rats. At the same dose it also showed a significant reduction in the formation of gastric lesion induced by water immersion and restraint stress. These results suggest that Salvianolic acid A shows antisecretory and antiulcer activity by inhibiting the gastric H⁺,K⁺-ATPase.

Key words

H⁺, K⁺-ATPase - acid secretion - anti-ulcer - anti-secretory - salvianolic acid A - Salvia miltiorrhiza

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