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Planta Med 1990; 56(5): 451-455
DOI: 10.1055/s-2006-961009
Paper

© Georg Thieme Verlag Stuttgart · New York

New Biologically Active Triterpene-Saponins from Randia dumetorum

Marie-Aleth Dubois1 , Sabine Benze2 , Hildebert Wagner2
  • 1Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Bourgogne, F-21033 Dijon Cedex, France
  • 2Institute of Pharmaceutical Biology, University of Munich, Karlstraße 29, D-8000 Munich 2, Federal Republic of Germany
Further Information

Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

Two new triterpene-saponins, 3-O-[O-β-D-glucopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→3)-(β-D-glucuronopyranosyl)]oleanolic acid (1), 3-O-[O-β-D-glucopyranosyl-(1→6)-O-β-D -glucopyranosyl-(1→3)-(β-D-glucuronopyranosyl)]oleanolic acid (2) together with five known saponins (3-7) were isolated from the methanolic extract of the fruits of Randia dumetorum (Retz) Lam. (Rubiaceae). Their structures were established on the basis of chemical and spectral data. The compounds 1,3,4,5 were found to enhance significantly the proliferation of human lymphocytes in vitro. The crude saponin fraction showed haemolytic, molluscici-dal, and immunostimulating activities.

Key words

Haemolytic activity - molluscicidal activity - immunostimulation - Randia dumetorum - triterpene-saponins

3 3 Part of a dissertation, University of Munich, 1990