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Planta Med 1992; 58(1): 35-38
DOI: 10.1055/s-2006-961385
Paper

© Georg Thieme Verlag Stuttgart · New York

Benzophenanthridine Alkaloids Isolated from Eschscholtzia californica Cell Suspension Cultures Interact with Vasopressin (V1) Receptors

I. Granger1 , C. Serradeil-le Gal2 , J. M. Augereau3 , J. Gleye2
  • 1Laboratoire de Pharmacognosie, Faculté des Sciences Pharmaceutiques, Allées Jules Guesdes, F-31400 Toulouse, France
  • 2Laboratoire de Biochimie Exploratoire, Sanofi Recherche, 195, Route d'Espagne, F-31036 Toulouse Cedex, France
  • 3Laboratoire de Phytotechnologie, Sanofi Elf Bio Recherches, B.P. 137, F-31328 Labege Cedex, France
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1991

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

Chelerythrine and sanguinarine, two benzophenanthridine alkaloids, have been isolated from a crude methanolic extract of Eschscholtzia californica cell suspension cultures by successive fractionations. These two molecules exhibited affinity for rat liver vasopressin V1 receptors and are competitive inhibitors of [3 H]-vasopressin binding within the micromolar range (Ki). Chelerythrine and sanguinarine represent two of the first non-peptidic structures providing original chemical leads for the design of synthetic vasopressin compounds.

Key words

Eschscholtzia californica - Papaveraceae - benzophenanthridine alkaloids - vasopressin V1-receptors