Download PDF
Planta Med 1992; 58(1): 51-55
DOI: 10.1055/s-2006-961389
Paper

© Georg Thieme Verlag Stuttgart · New York

Molluscicidal Constituents of Calophyllum from Madagascar: Activity of Some Natural and Synthetic Neoflavonoids and Khellactones

Bernard Ravelonjato1 , 2 , Francine Libot1 , Florence Ramiandrasoa1 , Nicole Kunesch1 , 4 , Philippe Gayral5 , Jacques Poisson1
  • 1Laboratoire de Chimie des Substances Thérapeutiques Naturelles, Faculté de Pharmacie, F-92296 Châtenay-Malabry Cedex, France
  • 2Département de Chimie, Centre National de Recherches Pharmaceutiques, B.P. 702, Androhibe, Antananarivo, Madagascar
  • 3Laboratoire des Médiateurs Chimiques, Domaine de Brouëssy, F-78470 Magny-les-Hameaux, France
  • 4CNRS-URA 1310
  • 5Laboratoire de Parasitologie, Faculté de Pharmacie, F-92296 Châtenay-Malabry CEDEX, France
Further Information

Publication History

1991

Publication Date:
04 January 2007 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

Crude extracts of seeds, leaves and barks of four Madagascan Calophyllum species: C. inophyllum, C. recedens, C. chapelieri, and C. verticillatum, have been tested for molluscicidal activity against Biomphalaria glabrata. All seed extracts showed significant activity. The major constituents of the most active Calophyllum species were examinated. Some related coumarinic derivatives were synthesized in order to improve the biological activity. Among the compounds prepared, 5,7-dihydroxy-6-(2-methylbutyryl)-4-phenylcoumarin presented an interesting molluscicidal activity.

Key words

Calophyllum species - Guttiferae Biomphalaria glabrata - molluscicidal activity - coumarins - khellactones - neoflavonoids