Tyromycin A: A Novel Inhibitor of Leucine and Cysteine Aminopeptidases from Tyromyces lacteus1

Wolfgang Weber; Martin Semar; Timm Anke; Monika Bross; Wolfgang Steglich

doi:10.1055/s-2006-961390

Planta Medica, Table of Contents

Planta Med 1992; 58(1): 56-59
DOI: 10.1055/s-2006-961390

Paper

Tyromycin A: A Novel Inhibitor of Leucine and Cysteine Aminopeptidases from Tyromyces lacteus ¹

Wolfgang Weber² , Martin Semar² , Timm Anke² , Monika Bross³ , Wolfgang Steglich³

²Lehrbereich Biotechnologie der Universität Kaiserslautern, Paul-Ehrlich-Str. 23, D(W)-6750 Kaiserslautern, Federal Republic of Germany
³Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard-Domagk-Str. 1, D(W)-5300 Bonn 1, Federal Republic of Germany

1 Part XL of the series “Antibiotics from Basisdiomycetes”; for part XXXIX, see Ref. (1)

Abstract

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Abstract

Tyromycin A, a new inhibitor of leucine and cysteine aminopeptidases has been isolated from mycelial cultures of the basidiomycete Tyromyces lacteus (Fr.) Murr. Its structure was established as 1,16-bis-[4-methyl-2,5-dioxo-3-furyl]hexadecane (1) by spectral analysis and transformation into ester and imide derivatives.

Key words

Tyromycin A - Tyromyces lacteus - amino-peptidase inhibitor - citraconic anhydride derivative

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Tyromycin A: A Novel Inhibitor of Leucine and Cysteine Aminopeptidases from Tyromyces lacteus 1

Tyromycin A: A Novel Inhibitor of Leucine and Cysteine Aminopeptidases from Tyromyces lacteus ¹