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Planta Med 1992; 58(1): 88-93
DOI: 10.1055/s-2006-961397
Paper

© Georg Thieme Verlag Stuttgart · New York

Microdontin A and B: Two New Aloin Derivatives from Aloe microdonta

Mohamed H. Farah1 , Rolf Andersson2 , Gunnar Samuelsson1
  • 1Department of Pharmacognosy, University of Uppsala, Biomedical Center, Box 579, S-751 23, Uppsala, Sweden
  • 2Department of Chemistry. Swedish University of Agricultural Sciences, Box 7015, S-75007 Uppsala, Sweden
Further Information

Publication History

1991

Publication Date:
04 January 2007 (online)

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Abstract

The leaf juice of Aloe microdonta Chiov. is used in Somali traditional medicine as a remedy for jaundice and for topical treatment of skin diseases. Mucilage was precipitated from the fresh juice by addition of ethanol and the supernatant chromatographed on Amberlite XAD-2 to yield a fraction containing anthraquinone derivatives. Flash chromatography on silica gel followed by preparative TLC yielded aloin A and a new compound. Spectral data (mass, 1H- and 13C-NMR) identified this compound as a mixture of aloin A and B where the glucose of both compounds is esterified with 4-hydroxycinnamic acid at the 6′-position. The two compounds were denoted as microdontin A and B, respectively.

Key words

Aloe microdonta - aloin derivatives - microdontin A and B - anthraquinones - leaf juice