Planta Medica, Inhaltsverzeichnis Planta Med 1992; 58(2): 146-149DOI: 10.1055/s-2006-961416 Papers © Georg Thieme Verlag Stuttgart · New York Choleretic Effect of Andrographolide in Rats and Guinea Pigs1 Binduja Shukla, P. K. S. Visen, G. K. Patnaik, B. N. Dhawan ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Research Institute, Lucknow-226 001 (U.P.), India 1 CDRI Communication No. 4763 Artikel empfehlen Abstract als PDF herunterladen Artikel einzeln kaufen Abstract Andrographolide from the herb Andrographis paniculata (whole plant) per se produces a significant dose (1.5-12 mg/kg) dependent choleretic effect (4.8-73%) as evidenced by increase in bile flow, bile salt, and bile acids in conscious rats and anaesthetized guinea pigs. The paracetamol induced decrease in volume and contents of bile was prevented significantly by andrographolide pretreatment. It was found to be more potent than silymarin, a clinically used hepatoprotective agent. Key words Andrographis paniculata - andrographolide - choleretic activity - hepatoprotective effects PDF (289 kb)
