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Planta Med 1992; 58(2): 166-170
DOI: 10.1055/s-2006-961421
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© Georg Thieme Verlag Stuttgart · New York

Mitogenic and Complement Activating Activities of the Herbal Components of Juzen-Taiho-To1

Haruki Yamada2 , Hiroaki Kiyohara2 , Norito Takemoto3 , Ji-Fu Zhao2 , 4 , Hideki Kawamura3 , Yasuhiro Komatsu3 , Jong-Chol Cyong2 , Masaki Aburada3 , Eikichi Hosoya3
  • 2Oriental Medicine Research Center of the Kitasato Institute, Minato-ku, Tokyo 108, Japan
  • 3Tsumura Research Institute for Pharmacology, Ibaraki 300-11, Japan
  • 4Shenyang Pharmaceutical College, Shenyang, China
1 Part III in the series “Studies on Immunologically Active Substances from Kampo Medicine, Juzen-Taiho-To”. For part I and II, see Refs. (5,6)
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Publication History

1990

Publication Date:
05 January 2007 (online)

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Abstract

The Kampo (Japanese herbal) medicine “Juzen-Taiho-To” (TJ-48), which was prepared by decocting a concoction (formula), contains ten kinds of herbs and has several immunostimulating activities. In order to determine the contribution of each herbal component, the complement-activating and mitogenic activities of the hot water extract as well as the polysaccharide fraction from each herb were tested. Hot water extracts of Glycyrrhizae radix, Astragali radix, and Atractylodis lanceae rhizoma showed significant mitogenic activity whereas that of Cinnamomi cortex showed potent complement-activating activity. However, the exclusion of any single component herb whether active or not on its own did not result in a loss or an increase of the overall activity of TJ-48. The polysaccharide fraction from Glycyrrhizae radix showed the most potent of both activities among the same fractions from the other nine herbs, and reduced both activities after periodate oxidation, thus indicating that the carbohydrate moiety may contribute to both activities.

Key words

Kampo (Japanese herbal) medicine - Juzen-Taiho-To - complement-activating activity - mitogenic activity - immunostimulating activity