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Planta Med 1992; 58(2): 200-204
DOI: 10.1055/s-2006-961429
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© Georg Thieme Verlag Stuttgart · New York

Studies on the Constituents of Adelostemma gracillimum

Quan-zhang Mu1 , Yue-mao Shen1 , Qian-lan Zhou1 , Shu-quan Wang2 , Bing Wu2 , Qi-tai Zheng2
  • 1Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming 650204, Yunnan, People's Republic of China
  • 2Institute of Materia Medica, Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing, People's Republic of China
Further Information

Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

The glycone portion of the glycoside of Adelostemma gracillimum Hook. f. (Asclepiadaceae) was investigated. Three known polyoxypregnane ester-type aglycones, penupogenin (1) (1, 2), kidjoranine (2) (1, 3), and gagamine (3) (4, 5), and one new compound named gracigenin (4) were isolated and their structures were characterized on the basis of spectroscopic evidence, and that of (4) was determined by X-ray crystallography. It was found to possess an unprecedented 8,14-seco-polyoxypregnane ester-type skeleton, and 4 is the first compound with this C21-steroid type skeleton to be found in nature.

Key words

Adelostemma gracillimum f. - gracigenin - Asclepiadaceae - 8,14-seco-polyoxypregnane esterotype skeleton