A Peptide from Schumanniophyton magnificum with Anti-Cobra Venom Activity

Peter J. Houghton; Ibironke M. Osibogun; Sukhi Bansal

doi:10.1055/s-2006-961449

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Planta Med 1992; 58(3): 263-265
DOI: 10.1055/s-2006-961449

Paper

A Peptide from Schumanniophyton magnificum with Anti-Cobra Venom Activity

Peter J. Houghton¹ , Ibironke M. Osibogun¹ , Sukhi Bansal³

¹Pharmacognosy Research Laboratories, Chelsea Department of Pharmacy, King's College London, Manresa Road, London SW3 6LX.U.K.
³Pharmaceutical Chemistry Research Laboratories, Chelsea Department of Pharmacy, King's College London. Manresa Road, London SW3 6LX, U.K.

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Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

Using the chick biventer cervicis preparation as a bioassay for antivenom activity, a peptide has been isolated from the aqueous extract of the bark of Schumanniophyton magnificum. The peptide was isolated and purified by a combination of reverse-phase and exclusion column chromatography, preparative TLC, and HPLC. The peptide has a relative molecular mass of about 6000 daltons and is similar in amino acid composition to the cardiotoxins present in snake venom. The isolated peptide showed dose-related inhibitions of the effects of cardiotoxin and total venom of cobra species using the chick biventer cervicis preparation.

Key words

Schumanniophyton magnificum - Rubiaceae - peptides - anti-snake venom activity