Activation of PC12 Cells by Lipophilic Components of Panax ginseng

Tetsuro Mohri; Kenzo Chiba; Matsumi Yamazaki; Mineo Shimizu; Naokata Morita

doi:10.1055/s-2006-961476

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Planta Med 1992; 58(4): 321-323
DOI: 10.1055/s-2006-961476

Papers

Activation of PC12 Cells by Lipophilic Components of Panax ginseng

Tetsuro Mohri¹ , Kenzo Chiba¹ , Matsumi Yamazaki¹ , Mineo Shimizu² , Naokata Morita²

¹The 2nd Division of the Research Laboratory for Development of Medicine, Hokuriku University School of Pharmacy, Kanazawa, Ishikawa 920-11, Japan
²Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama 930-01, Japan

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Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

The lipid soluble fraction of Panax ginseng C. A. Meyer has been found to possess a stimulatory effect on a para-neuronal culture cell line, namely PC12 cells. Addition of the diethyl ether extract (0.025-0.1 mg/ml) of Ginseng radix to a culture medium promoted the outgrowth of neurites from cells dose-dependently as well as their ready differentiation to respond to carbachol and high KCl-evoked membrane depolarization to induce free Ca²⁺ accumulation in the cells within a week of culture. Effective constituents of the extract were confined to four major substances detected in the extremely lipophilic front area on silica gel TLC.

Key words

Panax ginseng - lipophilic components - PC12 cells - neurite outgrowth - acetylcholine receptor