Planta Medica, Inhaltsverzeichnis Planta Med 1992; 58(4): 321-323DOI: 10.1055/s-2006-961476 Papers © Georg Thieme Verlag Stuttgart · New York Activation of PC12 Cells by Lipophilic Components of Panax ginseng Tetsuro Mohri1 , Kenzo Chiba1 , Matsumi Yamazaki1 , Mineo Shimizu2 , Naokata Morita2 1The 2nd Division of the Research Laboratory for Development of Medicine, Hokuriku University School of Pharmacy, Kanazawa, Ishikawa 920-11, Japan 2Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama 930-01, Japan Artikel empfehlen Abstract als PDF herunterladen Artikel einzeln kaufen Abstract The lipid soluble fraction of Panax ginseng C. A. Meyer has been found to possess a stimulatory effect on a para-neuronal culture cell line, namely PC12 cells. Addition of the diethyl ether extract (0.025-0.1 mg/ml) of Ginseng radix to a culture medium promoted the outgrowth of neurites from cells dose-dependently as well as their ready differentiation to respond to carbachol and high KCl-evoked membrane depolarization to induce free Ca2+ accumulation in the cells within a week of culture. Effective constituents of the extract were confined to four major substances detected in the extremely lipophilic front area on silica gel TLC. Key words Panax ginseng - lipophilic components - PC12 cells - neurite outgrowth - acetylcholine receptor PDF (217 kb)
