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Planta Med 1992; 58(4): 358-364
DOI: 10.1055/s-2006-961485
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© Georg Thieme Verlag Stuttgart · New York

New Ecdysteroids from Serratula tinctoria

D. Rudel1 , M. Bathori2 , J. Gharbi3 , J.-P. Girault3 , I. Racz2 , K. Melis2 , K. Szendrei2 , R. Lafont1
  • 1Ecole Normale Supérieure, Département de Biologie, Laboratoire de Biochimie et Physiologie du Développement, CNRS URA 686, 46 rue d'Ulm, F-75230 Paris Cedex 05, France
  • 2Albert Szent-Györgyi Medical University, Department of Pharmacognosy. P.O. Box 121, H-6701 Szeged, Hungary
  • 3Université René Descartes, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques. CNRS URA 400, 45 rue des Saints-Pères, F-75006 Paris, France
Further Information

Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

Six new ecdysteroids have been isolated from Serratula tinctoria; these are: the 2,22- and 3,22-diacetates of 20-hydroxyecdysone, 5β-hydroxyrubrosterone, 3-epi-poststerone, 3-epi-rubrosterone, and 22-oxo-20-hydroxyecdysone. These minor compounds were found together with the known ecdysteroids, 20-hydroxyecdysone, its 2-, 3-, and 22-monoacetates, rubrosterone, poststerone, polypodine B (5β,20-dihydroxyecdysone), pterosterone (25-deoxy-20,24-dihydroxyecdysone), and makisterone C (24-ethyl-20-hydroxyecdysone). All these ecdysteroids were isolated by a combination of several chromatographic techniques (liquid chromatography on alumina, DCCC, and HPLC), then identified using standard mass spectrometric and 2D 1H-NMR techniques.

Key words

Ecdysteroids - Compositae - Serratula