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Planta Med 1992; 58(5): 398-404
DOI: 10.1055/s-2006-961500
Paper

© Georg Thieme Verlag Stuttgart · New York

Effects of Skeletonema costatum Extracts on the Central Nervous System

R. Villar, M. R. Laguna, J. M. Calleja, I. Cadavid
  • Departamento de Farmacología, Farmacia y Tecnología Farmacéutica. Facultad de Farmacia, Universidad de Santiago de Compostela, Galicia, Spain
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Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

We report the effects of aqueous extracts of the microalga Skeletonema costatum Greve (Cleve) (Bacillariophyceae) on spontaneous motor activity, rectal temperature, motor coordination, amphetamineinduced hypermotility, exploratory behaviour, muscle relaxation, catalepsy, conditioned avoidance responses, oxotremorin-induced cholinergic syndrome, and pentylenetetrazole-induced convulsions. The S. costatum extract at dosages of 310 and 620mg/kg works like an antidopaminergic drug with anticholinergic properties, that does not induce catalepsy and with a notable muscle relaxing activity.

Key words

Skeletonema costatum - CNS activity - antidopaminergic drug - muscle relaxant activity - anticholinergic properties