Isolation, Identification, and Chemical Synthesis of 6α-Hydroxyraumacline: A Novel Alkaloid from Cultivated Rauwolfia serpentina Cells

Susanne Endreß; Shinya Suda; Hiromitsu Takayama; Norio Aimi; Shin-ichiro Sakai; Joachim Stöckigt

doi:10.1055/s-2006-961502

Planta Medica, Table of Contents

Planta Med 1992; 58(5): 410-412
DOI: 10.1055/s-2006-961502

Paper

Isolation, Identification, and Chemical Synthesis of 6α-Hydroxyraumacline: A Novel Alkaloid from Cultivated Rauwolfia serpentina Cells

Susanne Endreß¹ , Shinya Suda² , Hiromitsu Takayama² , Norio Aimi² , Shin-ichiro Sakai² , Joachim Stöckigt¹

¹Lehrstuhl für Pharmazeutische Biologie der Johannes Gutenberg-Universität Mainz. Institut für Pharmazie. Staudinger Weg5, D(W)-6500 Mainz. Federal Republic of Germany.
²Faculty of Pharmaceutical Sciences. Chiba University. 1-33. Yayoi-cho. Chiba. 260 Japan

Abstract

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Abstract

From Rauwolfia serpentina cells cultivated in the presence of ajmaline (2) the new indole alkaloid, 6α-hydroxyraumacline (1), was isolated. This alkaloid also occurs in significant amounts in the nutrition medium. A simple chemical synthesis of 1 was developed starting from ajmaline (2).

Keyword

Rauwolfia serpentina cell culture - Apocynaceae - ajmaline biotransformation - 6α-hydroxyraumacline - synthesis

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