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Planta Med 1992; 58(5): 429-431
DOI: 10.1055/s-2006-961506
Paper

© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Activity of Cardenolides from Beaumontia brevituba Stems1

N. Kaneda2 , H. Chai2 , J. M. Pezzuto2 , A. D. Kinghorn2 , N. R. Farnsworth2 , P. Tuchinda3 , J. Udchachon3 , T. Santisuk4 , V. Reutrakul3
  • 2Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago. Illinois 60612, U.S.A.
  • 3Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10900, Thailand
  • 4The Forest Herbarium, Royal Forestry Department, Bangkok 10400, Thailand
1 Plant Anticancer Agents. XLIX. For Part XLVIII, see Ref. (1)
Further Information

Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

Five known cardenolides, digitoxigenin (1), oleandrigenin (2), digitoxigenin α-L-cymaroside (3), digitoxigenin β-gentiobiosyl-α-L-cymaroside (4), and δ16-digitoxigenin β-D-glucosyl-α-L-cymaroside (5), were isolated from the stems of Beaumontia brevituba Oliver by cytotoxicity-directed fractionation monitored by a cultured human lung cancer cell line. The cytotoxic activity of these compounds was evaluated with a panel of twelve human and murine cancer cell lines. The lignan glycoside, syringaresinol β-D-glucoside, was obtained for the first time in the form of its levo-enantiomer.

Key words

Beaumontia brevituba - Apocynaceae - cardenolides - cytotoxicity - lignan - structure elucidation