Effect of Gomisin A (TJN-101) on Liver Regeneration

Shoji Kubo; Yasufumi Ohkura; Yasuhiro Mizoguchi; Isao Matsui-Yuasa; Shuzo Otani; Seiji Morisawa; Hiroaki Kinoshita; Shigefumi Takeda; Masaki Aburada; Eikichi Hosoya

doi:10.1055/s-2006-961532

Planta Med 1992; 58(6): 489-492
DOI: 10.1055/s-2006-961532

Papers

Effect of Gomisin A (TJN-101) on Liver Regeneration

Shoji Kubo¹ , Yasufumi Ohkura² , Yasuhiro Mizoguchi² , Isao Matsui-Yuasa³ , Shuzo Otani³ , Seiji Morisawa³ , Hiroaki Kinoshita¹ , Shigefumi Takeda⁴ , Masaki Aburada⁴ , Eikichi Hosoya⁴

¹Second Department of Surgery, Osaka City University Medical School, 1-5-7, Asahi-machi, Abeno-ku, Osaka 545, Japan
²Third Department of Internal Medicine, Osaka City University Medical School, 1-5-7, Asahi-machi, Abeno-ku, Osaka 545, Japan
³Department of Biochemistry, Osaka City University Medical School, 1-5-7, Asahi-machi, Abeno-ku, Osaka 545, Japan
⁴Tsumura Research Institute for Pharmacology, 3586, Yoshiwara, Ami-machi, Inashiki-gunn, Ibaraki 300-11, Japan

Abstract

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Abstract

We studied the effect of TJN-101, a lignan component of Schisandra fruits (Schisandrae fructus), on liver regeneration after partial hepatectomy. TJN-101 was given orally to male Wistar rats 30 min before partial hepatectomy. The mitotic index and the level of DNA synthesis increased after partial hepatectomy and their increase was significantly enhanced by TJN-101. Ornithine decarboxylase (ODC) activity increased in the early stages of liver regeneration and it was also significantly enhanced by TJN-101. Besides, TJN-101 enhanced the increase in hepatic putrescine. These results suggest that TJN-101 stimulates liver regeneration after partial hepatectomy by enhancing ODC activity, which is an important biochemical event in the early stages of liver regeneration.

Key words

TJN-101 - Schisandra fruits (Schisandrae fructus) - liver regeneration - mitosis - polyamines - ornithine decarboxylase

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