Structure and Hepatoprotective Activity of a Biflavonoid from Canarium manii

K. K. Anand; V. N. Gupta; V. Rangari; Bhupinder Singh; B. K. Chandan

doi:10.1055/s-2006-961533

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Planta Med 1992; 58(6): 493-495
DOI: 10.1055/s-2006-961533

Papers

Structure and Hepatoprotective Activity of a Biflavonoid from Canarium manii

K. K. Anand¹ , V. N. Gupta¹ , V. Rangari² , Bhupinder Singh¹ , B. K. Chandan¹

¹Department of Pharmacology, Regional Research Laboratory, Canal Road, Jammu-Tawi 180 001, India
²College of Pharmacy, Nasik 422 001, India

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Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

Canarium manii (Burseraceae) was chemically investigated and the presence of the biflavonoid agathisflavone is reported for the first time from this plant. Pharmacologically, this biflavonoid in doses 50.0 mg and 100.0 mg given orally exhibited dose-dependent hepatoprotective activity against experimentally-induced carbon tetrachloride-hepatotoxicity in rats and mice.

Key words

Canarium manii - nutshell - biflavonoid - hepatoprotective activity - CCl4-induced hepatotoxicity