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Planta Med 1992; 58(6): 505-508
DOI: 10.1055/s-2006-961536
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© Georg Thieme Verlag Stuttgart · New York

Histamine Release Inhibition Activity of Bisbenzylisoquinoline Alkaloids

Kazuhiro Nakamura1 , Shuichi Tsuchiya1 , Yukihiro Sugimoto1 , Yukio Sugimura1 , Yasuyuki Yamada2
  • 1Tochigi Research Laboratories, Kao Corporation, 2606 Akabane, Ichikai-machi, Tochigi 321-34, Japan
  • 2Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan
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Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

Eleven examples of bisbenzylisoquinoline alkaloids (head-to-head; 10, head-to-tail; 1) and one half molecule type N-methylcoclaurine), were tested by in vitro histamine release inhibition assay. The order of the potency of the inhibitory effect was ranked thus; homoaromoline, aromoline, isotetrandrine, cepharanthine, fangchinoline, obaberine, and tetrandrine. The following substances, cepharanoline, berbamine, oxyacanthine, and cycleanine (head-to-tail structure) had no inhibitory effect. N-Methylcoclaurine showed an inhibitory effect comparable to that of fangchinoline.

Key words

Bisbenzylisoquinoline alkaloids - histamine release inhibition activity - rat basophilic leukemia (RBL-2H3) cells - antiallergic effect