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Planta Med 1992; 58(6): 513-515
DOI: 10.1055/s-2006-961538
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© Georg Thieme Verlag Stuttgart · New York

Hypoglycemic Activity of Olive Leaf

M. Gonzalez1 , A. Zarzuelo1 , M. J. Gamez1 , M. P. Utrilla1 , J. Jimenez1 , I. Osuna2
  • 1Departamento de Farmacologia, Facultad de Farmacia, Universidad de Granada, 18071 Granada, Spain
  • 2Departamento de Bioquimica, Facultad de Medicina, Universidad de Granada, 18071 Granada, Spain
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Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

The hypoglycemic activity of olive leaf was studied. Maximum hypoglycemic activity was obtained from samples collected in the winter months, especially in February. One of the compounds responsible for this activity was oleuropeoside, which showed activity at a dose of 16 mg/kg. This compound also demonstrated antidiabetic activity in animals with alloxan-induced diabetes. The hypoglycemic activity of this compound may result from two mechanisms: (a) potentiation of glucose-induced insulin release, and (b) increased peripheral uptake of glucose.

Key words

Olea europaea - olive leaf - hypoglycemic activity - oleuropeoside - seasonal variation