Effects of Three Compounds Extracted from Morinda lucida on Plasmodium falciparum

K. Koumaglo; M. Gbeassor; O. Nikabu; C. de Souza; W. Werner

doi:10.1055/s-2006-961543

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Planta Med 1992; 58(6): 533-534
DOI: 10.1055/s-2006-961543

Papers

Effects of Three Compounds Extracted from Morinda lucida on Plasmodium falciparum

K. Koumaglo¹ , M. Gbeassor² , O. Nikabu¹ , C. de Souza³ , W. Werner⁴

¹Département de Chimie, Université du Bénin, BP. 1515, Lomé, Togo
²Département de Physiologie, Faculté des Sciences, Université du Bénin, BP. 1515, Lomé, Togo
³Laboratoire de Biologie Cellulaire et de Génétique, IUT de Santé et des Sciences Biologiques; Université du Bénin, BP. 1515, Lomé, Togo
⁴Institut für Pharmazeutische Chemie, Westfälische Wilhelms-Universität, Hittorfstr. 58-62, D(W)-4400 Münster, Federal Republic of Germany

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Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

The effects of three compounds, digito-lutein (1), rubiadin 1-methyl ether (2) and damnacanthal (3) extracted from the stem bark and the roots of Morinda lucida Benth. on the growth of Plasmodium falciparum in vitro were investigated. The number of parasites (schizonts) decreased significantly in a dose-dependent manner, and 100% of inhibition was obtained with 30 to 40 μg of each compound tested. The IC₅₀ values were calculated.

Key words

Morinda lucida - Rubiaceae - anthraquinones - Plasmodium falciparum