Cajucarinolide and Isocajucarinolide: Anti-Inflammatory Diterpenes from Croton cajucara

Yoshitatsu Ichihara; Koichi Takeya; Yukio Hitotsuyanagi; Hiroshi Morita; Satomi Okuyama; Masami Suganuma; Hirota Fujiki; Mario Motidome; Hideji Itokawa

doi:10.1055/s-2006-961547

Planta Med 1992; 58(6): 549-551
DOI: 10.1055/s-2006-961547

Papers

Cajucarinolide and Isocajucarinolide: Anti-Inflammatory Diterpenes from Croton cajucara

Yoshitatsu Ichihara¹ , Koichi Takeya¹ , Yukio Hitotsuyanagi¹ , Hiroshi Morita¹ , Satomi Okuyama¹ , Masami Suganuma² , Hirota Fujiki² , Mario Motidome³ , Hideji Itokawa¹

¹Department of Pharmacognosy, Tokyo College of Pharmacy, Horinouchi 1432-1, Hachioji, 192-03 Tokyo, Japan
²Cancer Prevention Division, National Cancer Center Research Institute, Chuo-ku 5-1-1, 104 Tokyo, Japan
³Institute de Quimica, Universidade de Sao Paulo, 05508 Sao Paulo, Brazil

Abstract

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Abstract

Cajucarinolide and isocajucarinolide, two new clerodane diterpenes, have been isolated from the cortices of Croton cajucara (Euphorbiaceae). These compounds possess anti-inflammatory activity and inhibit bee venom phospholipase A₂ in vitro.

Key words

Cajucarinolide - isocajucarinolide - clerodane diterpene - Croton cajucara - Euphorbiaceae - phospholipase A₂ inhibitor - anti-inflammation - teleocidin

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