Tussilagine and Isotussilagine: Two Pyrrolizidine Alkaloids in the Genus Arnica1

Claus M. Paßreiter; Günter Willuhn; Erhard Röder

doi:10.1055/s-2006-961549

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Planta Med 1992; 58(6): 556-557
DOI: 10.1055/s-2006-961549

Papers

Tussilagine and Isotussilagine: Two Pyrrolizidine Alkaloids in the Genus Arnica ¹

Claus M. Paßreiter¹ , Günter Willuhn¹ , Erhard Röder²

¹Institut für Pharmazeutische Biologie der Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, D(W)-4000 Düsseldorf, Federal Republic of Germany
²Pharmazeutisches Institut der Rheinischen Friedrich-Wilhelms-Universität Bonn, An der Immenburg 4, D(W)-5300 Bonn-Endenich, Federal Republic of Germany

1 Presented at the 39th Annual Congress on Medicinal Plant Research, 3.-7. September, Saarbrücken, 1991; see: Paßreiter, C. M., Willuhn, G., Röder, E. (1991) Planta Med. 57, A106

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Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

In flowerheads of Arnica montana, A. chamissonis ssp. foliosa, A. amplexicaulis, and A. sachalinensis, traces of the non-toxic pyrrolizidine alkaloids tussilagine and isotussilagine were detected. Their identity was unambiguously confirmed by direct comparison (TLC, GC, GC/MS) with the authentic samples.

Key words

Arnica species - pyrrolizidine alkaloids - isotussilagine - tussilagine - toxicity