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Planta Med 1989; 55(1): 48-50
DOI: 10.1055/s-2006-961823
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© Georg Thieme Verlag Stuttgart · New York

Antihepatotoxic Principles of Solanum capsicastrum 1

Chun-Nan Lin, Kim-Hong Gan
  • School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Taiwan 80731, Republic of China
1 Part V in the series “Studies on the constituents of Formosan Solanum species”. For part IV, see: Lin, C.-N., Chung, M.-I, Gan, K.-H. (1988) Planta Med. 54, 222
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Publication History

1988

Publication Date:
24 January 2007 (online)

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Abstract

Two new steroidal alkaloids named capsimine and isocapsicastrine were isolated from the root bark of Solanum capsicastrum. Their structures were elucidated by chemical degradation and spectral data as (22R,25R)-22,26-epiminocholest-5-ene-3β,16α-diol and (22S,25S)-O(3)-β-D-glucopyranosyl-22,26-epiminocholest-5-ene-3β-16α-diol, respectively. Capsicastrine, capsicastrine acetate, isoteinemine acetate, and etioline exhibited strong activity against liver damage induced by CCl4.