Anti-Inflammatory Activity of 5,7-Dimethoxyflavone

A. Panthong; W. Tassaneeyakul; D. Kanjanapothi; P. Tantiwachwuttikul; V. Reutrakul

doi:10.1055/s-2006-961905

Planta Medica, Table of Contents

Planta Med 1989; 55(2): 133-136
DOI: 10.1055/s-2006-961905

Papers

Anti-Inflammatory Activity of 5,7-Dimethoxyflavone

A. Panthong¹ , W. Tassaneeyakul¹ , D. Kanjanapothi¹ , P. Tantiwachwuttikul² , V. Reutrakul³

¹Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50002, Thailand
²Department of Chemistry, Silapakorn University, Nakhon Pathom 73000, Thailand
³Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

Abstract

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Abstract

The anti-inflammatory activity of 5,7-dimethoxyflavone (5,7-DMF) has been assessed. It was found to possess a comparable effect to aspirin on the rat paw edema model, and it showed no inhibition on cotton pellet-induced granuloma formation. On the rat pleurisy model, 5,7-DMF exhibited an antiexudative effect, interfered with leukocyte migration, and markedly inhibited prostaglandin biosynthesis. In addition, 5,7-DMF cuased marked lowering of the rectal temperature of rats. The results obtained from Hippocratic screening revealed that 5,7-DMF possessed a weak CNS depressant activity.

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