Anti-Inflammatory Activity of 5,7-Dimethoxyflavone

A. Panthong; W. Tassaneeyakul; D. Kanjanapothi; P. Tantiwachwuttikul; V. Reutrakul

doi:10.1055/s-2006-961905

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000058.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Planta Med 1989; 55(2): 133-136
DOI: 10.1055/s-2006-961905

Papers

Anti-Inflammatory Activity of 5,7-Dimethoxyflavone

A. Panthong¹ , W. Tassaneeyakul¹ , D. Kanjanapothi¹ , P. Tantiwachwuttikul² , V. Reutrakul³

¹Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50002, Thailand
²Department of Chemistry, Silapakorn University, Nakhon Pathom 73000, Thailand
³Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

Further Information

Publication History

1988

Publication Date:
24 January 2007 (online)

Also available at

PDF Download Permissions and Reprints

Abstract

The anti-inflammatory activity of 5,7-dimethoxyflavone (5,7-DMF) has been assessed. It was found to possess a comparable effect to aspirin on the rat paw edema model, and it showed no inhibition on cotton pellet-induced granuloma formation. On the rat pleurisy model, 5,7-DMF exhibited an antiexudative effect, interfered with leukocyte migration, and markedly inhibited prostaglandin biosynthesis. In addition, 5,7-DMF cuased marked lowering of the rectal temperature of rats. The results obtained from Hippocratic screening revealed that 5,7-DMF possessed a weak CNS depressant activity.