Cytotoxicity of Isoquinoline Alkaloids and Their N-Oxides1

Yang-Chang Wu; Yei-Fei Liou; Sheng-Teh Lu; Chung-Hsiung Chen; Jer-Jang Chang; Kuo-Hsiung Lee

doi:10.1055/s-2006-961913

Planta Medica, Table of Contents

Planta Med 1989; 55(2): 163-165
DOI: 10.1055/s-2006-961913

Papers

Cytotoxicity of Isoquinoline Alkaloids and Their N-Oxides¹

Yang-Chang Wu² , Yei-Fei Liou³ , Sheng-Teh Lu⁴ , Chung-Hsiung Chen² , Jer-Jang Chang⁵ , Kuo-Hsiung Lee²

²Natural Products Laboratory, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, U.S.A.
³Department of Microbiology, School of Medicine, Kaohsiung Medical College, Kaohsiung 80731, Taiwan, Republic of China
⁴Department of Pharmacognosy, School of Pharmacy, Kaohsiung Medical College, Kaohsiung 80731, Taiwan, Republic of China
⁵Division of Laboratory Animal Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, U.S.A.

1 Antitumor Agents: CIII. For paper CII in this series, see Lin, Y. M., Hung, J. C., Chen, F. C., Lee, K. H., Planta Med., in press

Abstract

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Abstract

A series of 53 isoquinoline alkaloids and their N-oxides have been tested for their cytotoxicity against A-549, HCT-8, KB, P-388, and L-1210 cells. These alkaloids include two tetrahydroprotoberberines, two protoberberines, six aporphines, one morphinandienone, five oxoaporphines, seven phenanthrenes, one spirobenzylisoquinoline N-oxide, nine aporphine N-oxides, seven benzyltetrahydroisoquinoline N-oxides, one benzylisoquinoline N-oxide, one protopine N-oxide, three tetrahydroprotoberberine N-oxides, four pavine N-oxides, and four phenanthrene N-oxides. The results are discussed on the basis of structure-activity relationships.

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