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Planta Med 1989; 55(4): 349-350
DOI: 10.1055/s-2006-962025
DOI: 10.1055/s-2006-962025
Papers
© Georg Thieme Verlag Stuttgart · New York
Isolation and Hypoglycemic Activity of Trichosans A, B, C, D, and E: Glycans of Trichosanthes kirilowii Roots1
1 Antidiabetes drugs, Part. 29. Also Part 132 in the validity of the Oriental medicinesFurther Information
Publication History
1988
Publication Date:
24 January 2007 (online)
Abstract
The non-dialyzable portion of the water extract of the Oriental crude drug “karokon”, the roots of Trichosanthes kirilowii, was found to reduce the plasma glucose level in mice. Activity-guided fractionation of this non-dialyzable portion led to the isolation of five glycans termed as trichosans A, B, C, D and E, showing hypoglycemic actions in normal mice. The main glycan, trichosan A, also exhibited activity in alloxan-induced hyperglycemic mice.