Modification of Catharanthus roseus Alkaloids: A Lactone Derived from 17-Deacetylvinblastine

André De Bruyn; Maurice Verzele; Jean-Paul Dejonghe; K. S. P. Bhushana Rao; Marie-Paule Collard; André Trouet; Jean Hannart

doi:10.1055/s-2006-962029

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Planta Med 1989; 55(4): 364-366
DOI: 10.1055/s-2006-962029

Papers

Modification of Catharanthus roseus Alkaloids: A Lactone Derived from 17-Deacetylvinblastine

André De Bruyn¹ , Maurice Verzele¹ , Jean-Paul Dejonghe² , K. S. P. Bhushana Rao² , Marie-Paule Collard² , André Trouet² , Jean Hannart³

¹Rijksuniversiteit Gent, Laboratorium voor Organische Chemie, Krijgslaan, 281 (S.4), B-9000 Gent, Belgium
²IRE-CELLTARG, 75.39, avenue Hippocrate, B-1200 Bruxelles, Belgium
³OMNICHEM-GECHEM, Parc Scientifique, rue du Fonds Jean-Pâques 8, B-1348 Louvain-la-Neuve, Belgium

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Publication History

1988

Publication Date:
24 January 2007 (online)

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Abstract

A spirolactone with anti-tumor activity is formed during the reaction of paraformaldehyde with 17-deacetylvinblastine. The compound was identified by NMR techniques. The chemotherapeutic activity was assessed.