Silybin Dihemisuccinate Protects Against Glutathione Depletion and Lipid Peroxidation Induced by Acetaminophen on Rat Liver

Rolando Campos; Argelia Garrido; Ricardo Guerra; Alfonso Valenzuela

doi:10.1055/s-2006-962055

RSS-Feed abonnieren

Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.

https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000058.xml

Teilen / Bookmarken

Facebook X Linkedin Weibo

PDF herunterladen

Planta Med 1989; 55(5): 417-419
DOI: 10.1055/s-2006-962055

Papers

Silybin Dihemisuccinate Protects Against Glutathione Depletion and Lipid Peroxidation Induced by Acetaminophen on Rat Liver

Rolando Campos, Argelia Garrido, Ricardo Guerra, Alfonso Valenzuela

Laboratorio de Bioquímica Farmacológica, Instituto de Nutrición y Tecnología de los Alimentas. Universidad de Chile, Casilla 15138, Santiago 11, Chile

Weitere Informationen

Publikationsverlauf

1988

Publikationsdatum:
24. Januar 2007 (online)

Auch verfügbar auf

als PDF herunterladen Lizenzen und Reprints

Abstract

Acetaminophen hepatotoxicity is characterized by glutathione depletion, cellular necrosis, and, in some instances, by the induction of lipid peroxidation. Silybin dihemisuccinate, a soluble form of the flavonoid silymarin, protects rats against liver glutathione depletion and lipid peroxidation induced by acute acetaminophen intoxication. Other biochemical parameters such as serum transaminases did not show the drastic increase observed under acetaminophen intoxication when animals were treated with the flavonoid. Preliminary results suggest that silybin dihemisuccinate may be another antidote against acetaminophen hepatotoxicity.