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Planta Med 1988; 54(1): 4-6
DOI: 10.1055/s-2006-962317
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© Georg Thieme Verlag Stuttgart · New York

Effect of Novel 7β-Derivatives of Forskolin upon Human Platelet Adenylate Cyclase System

E. Seguin1 , N. Ferry2 , J. Hanoune2 , M. Koch1
  • 1Département de Pharmacognosie, UA CNRS 484, Université Paris 5, 4 Avenue de l'Observatoire, F-75006 Paris, France.
  • 2INSERM U-99, Hôpital Henri Mondor, F-94010 Créteil, France.
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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

We have synthesized different 7β-derivatives of the diterpene forskolin, which are presumably more hydrophilic than the parent compound. Their activity was tested on the adenylate cyclase system of human platelet membranes. The 7β-glyceryl and 7β-dimethylacryloyl derivatives were as potent as native forskolin while 7-deacetylforskolin was 10 fold less active. Pyranosyl derivatives were unable to stimulate adenylate cyclase although they displayed a weak antagonistic effect against forskolin activation.