Abstract
Extracts of leaves and flowers of Centaurea corcubionensis Lainz have been assayed for hypoglycemie activity in normo- and hyperglycemic rats. Infusion of an active dose of 5 g/kg lowered blood glucose levels by 16-19% and increased circulating insulin by 27-50%. Heavy release of insulin from islets of Langerhans isolated from rat pancreas was induced by doses of 25, 50, and 100 mg/ml. Infusions induced a significant fall in glycemia levels in rats with glucose-induced hyperglycemia, but had no effect on alloxan-diabetic animals.
