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Planta Med 1988; 54(2): 120-122
DOI: 10.1055/s-2006-962366
DOI: 10.1055/s-2006-962366
Papers
© Georg Thieme Verlag Stuttgart · New York
Plant Based Antiamoebic Drugs; Part II1. Amoebicidal Activity of Parthenin Isolated from Parthenium hysterophorus 2
1 For paper I in this series see Ref. (1).2 Part of this data was presented at the 1st. Asian Congress of Pharmacology, New Delhi, January, 1985.Further Information
Publication History
1987
Publication Date:
24 January 2007 (online)
Abstract
Parthenin, an α-methylene-γ-lactone sesquiterpene isolated from Parthenium hysterophorus is shown to possess antiamoebic activity. This activity was tested in vitro against axenic and polyxenic cultures of Entamoeba histolytica and was found to be comparable to that of the standard drug metronidazole. The acute toxicity of parthenin has been determined and this natural product was found effective in experimental hepatic amoebiasis.