Effect of Saponins from Anagallis arvensis on Experimental Herpes Simplex Keratitis in Rabbits

M. Amoros; B. Fauconnier; R.-L. Girre

doi:10.1055/s-2006-962369

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Planta Med 1988; 54(2): 128-131
DOI: 10.1055/s-2006-962369

Papers

Effect of Saponins from Anagallis arvensis on Experimental Herpes Simplex Keratitis in Rabbits

M. Amoros¹ , B. Fauconnier² , R.-L. Girre¹

¹Laboratoire de Pharmacognosie, Faculté de Pharmacie, Avenue du Pr. Léon-Bernard, F-35043 Rennes Cédex, France.
²Laboratoire de Virologie, Faculté de Médecine, Avenue du Pr. Léon-Bernard, F-35043 Rennes Cédex, France.

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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

Herpetic keratitis induced in rabbit eyes was experimentally treated with triterpene saponins from Anagallis arvensis (Primulaceae) and antiviral drugs: idoxuridine, adenine arabinoside, and acycloguanosine. Saponin ointment appeared to be as effective as adenine arabinoside and from days 10 to 14 post inoculation was better than idoxuridine; the most active compound being acycloguanosine.