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Planta Med 1988; 54(3): 193-196
DOI: 10.1055/s-2006-962401
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© Georg Thieme Verlag Stuttgart · New York

Hypotensive Constituents of Marine Algae; 1. Pharmacological Studies of Laminine

J. P. Girard1 , C. Marion1 , M. Liutkus2 , M. Boucard2 , E. Rechencq1 , J. P. Vidal1 , J. C. Rossi1
  • 1Unité Associée au CNRS, Chimie des Médiateurs et Physicochimie des Interactions Biologiques, Laboratoire de Chimie Organique, Faculté de Pharmacie, F-34060 Montpellier, France.
  • 2Laboratoire de Pharmacodynamie, Faculté de Pharmacie, F-34060 Montpellier, France.
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Publication History

1986

Publication Date:
24 January 2007 (online)

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Abstract

The effect on blood pressure of laminine (5-amino-5-carboxypentyltrimethylammonium hydroxide), which is widely distributed in brown algae of the Laminariaceae family, was studied to see if it contributes to the hypotensive activity of these algae which have been used for centuries in oriental medicine. The results show that this compound, at high doses, does have a hypotensive action as a result of a ganglion-blocking effect. As laminine is only present in low concentrations in these algae, its ganglion-blocking activity is not responsible for their hypotensive effect.