Thyroid Stimulatory Action of (Z)-Guggulsterone: Mechanism of Action

Y. B. Tripathi; Pratibha Tripathi; O. P. Malhotra; S. N. Tripathi

doi:10.1055/s-2006-962431

Planta Medica, Inhaltsverzeichnis

Planta Med 1988; 54(4): 271-277
DOI: 10.1055/s-2006-962431

Papers

Thyroid Stimulatory Action of (Z)-Guggulsterone: Mechanism of Action

Y. B. Tripathi¹ , Pratibha Tripathi² , O. P. Malhotra³ , S. N. Tripathi²

¹Biochemistry Section, Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, India.
²Department of Kayachikitsa, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, India.
³Department of Biochemistry, Faculty of Sciences, Banaras Hindu University, Varanasi - 221 005, India.

Abstract

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Abstract

(Z)-Guggulsterone, a ketosteroid isolated from the oleoresin of the dry exudate of Commiphora mukul, has been shown to stimulate the thyroid function in rats. This drug is now shown to counteract the thyroid-suppressant activity of a known thyroid inhibitor (carbimazole). This set of observations distinguishes the thyroid stimulatory action of (Z)-guggulsterone from that of the thyroid stimulatory hormone (TSH) of pituitary origin. It is, therefore, concluded that the action of (Z)-guggulsterone is not mediated by the pituitary.

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