Teratological Evaluation of Plectranthus fruticosus Leaf Essential Oil

N. Pages; M. Salazar; G. Chamorro; G. Fournier; M. Paris; S. M. Dumitresco; C. Boudene

doi:10.1055/s-2006-962437

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Planta Med 1988; 54(4): 296-298
DOI: 10.1055/s-2006-962437

Papers

Teratological Evaluation of Plectranthus fruticosus Leaf Essential Oil

N. Pages¹ , M. Salazar¹ , G. Chamorro¹ , G. Fournier² , M. Paris² , S. M. Dumitresco³ , C. Boudene¹

¹Laboratoire de Toxicologie, Faculté de Pharmacie, 5 Rue J.-B. Clément, F-92296 Châtenay-Malabry, France.
²Laboratoire de Pharmacognosie, Faculté de Pharmacie, 5 Rue J.-B. Clément, F-92296 Châtenay-Malabry, France.
³Laboratoire de Microbiologie et d'Immunologie (Universitaire et INSERM), Faculté de Chirurgie Dentaire de l'Université René Descartes, 1 rue Maurice Arnoux, F-92120 Montrouge, France.

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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

Pregnant female Wistar rats were administered Plectranthus fruticosus L'Hérit. (Labiatae) essential oil (0.5, 2.5, or 5.0 mg/kg/day) or olive oil orally on days 6 to 15 of gestation. The fetuses were removed for examination on day 20 of gestation. Essential oil was not maternotoxic, but it induced embryotoxicity as manifested by increased resorptions and malformations. The observed malformations were predominantly related to eyes for dosis > 5 mg/kg.