Antitumor Constituents from Bulbs of Crocosmia crocosmiiflora

Norio Nagamoto; Hideto Noguchi; Akira Itokawa; Katsuhisa Nakata; Kensuke Namba; Haruki Nishimura; Matao Matsui; Mizuo Mizuno

doi:10.1055/s-2006-962440

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Planta Med 1988; 54(4): 305-307
DOI: 10.1055/s-2006-962440

Papers

Antitumor Constituents from Bulbs of Crocosmia crocosmiiflora

Norio Nagamoto¹ , Hideto Noguchi¹ , Akira Itokawa¹ , Katsuhisa Nakata¹ , Kensuke Namba¹ , Haruki Nishimura¹ ^, [4] , Matao Matsui² , Mizuo Mizuno³

¹Research Laboratories, Dainippon Pharmaceutical Co., Ltd., 33-94 Enoki-cho, Suita, Osaka 564, Japan.
²Daiichi College of Pharmaceutical Sciences, 22-1 Tamagawa-cho, Minami-ku, Hukuoka 815, Japan.
³Gifu Pharmaceutical University, 6-1 Mitahorahigashi 5-chome, Gifu 502, Japan.

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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

The water extract from the bulbs of Crocosmia crocosmiiflora (Nicholson) N. E. Br. (Iridaceae) and its pass-through fraction obtained by gel-filtration chromtography showed strong antitumor activity against Ehrlich carcinoma ascites and solid in Jcl-ICR mice when administered intraperitoneally. Some chemical studies revealed that the active principles in this plant were saponins consisting of medicagenic acid and polygalacic acid as the major sapogenins, and glucose, xylose, arabinose, rhamnose, and fucose as the sugar moieties.

4 Deceased.