Cytotoxic and Antitumor Activities of Rabdosia Diterpenoids

Tetsuro Fujita; Yoshio Takeda; Sun Han-dong; Yoshinori Minami; Teruyoshi Marunaka; Setsuo Takeda; Yuji Yamada; Tsuneo Togo

doi:10.1055/s-2006-962485

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Planta Med 1988; 54(5): 414-417
DOI: 10.1055/s-2006-962485

Papers

Cytotoxic and Antitumor Activities of Rabdosia Diterpenoids

Tetsuro Fujita¹ ^, ² , Yoshio Takeda¹ , Sun Han-dong³ , Yoshinori Minami⁴ , Teruyoshi Marunaka⁴ , Setsuo Takeda⁴ , Yuji Yamada⁴ , Tsuneo Togo⁴

¹Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770, Japan.
²Faculty of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, 606, Japan.
³Kunming Institute of Botany, The Academy of Sciences of China, Kunming, Yunnan, People's Republic of China.
⁴Research Laboratory, Taiho Pharmaceutical Co., Ltd., Tokushima 771-01, Japan.

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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

Twenty-four diterpenoids from the plant of the genus Rabdosia, Labiatae, were examined for the cytotoxic activity against HeLa cells and several of them were examined for their effects on the life span of mice inoculated with Ehrlich ascites carcinoma cells. All the tested compounds except for sculponeatin B (19) and isodonal (21) showed stronger in vitro activity than oridonin (11) used as positive control. The results also showed that leukamenin B (2), kambebanin (6), effusanin A (14), and sculponeatin C (20) are the most effective in vivo among the tested compounds.