Antihepatotoxic Principles of Liquidambar formosana Fruits1

Chohachi Konno; Yoshiteru Oshima; Hiroshi Hikino; Ling-Ling Yang; Kun-Ying Yen

doi:10.1055/s-2006-962486

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Planta Med 1988; 54(5): 417-419
DOI: 10.1055/s-2006-962486

Papers

Antihepatotoxic Principles of Liquidambar formosana Fruits¹

Chohachi Konno² , Yoshiteru Oshima² , Hiroshi Hikino² , Ling-Ling Yang³ , Kun-Ying Yen³

²Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai 980, Japan.
³Taipei Medical College, Taipei, Republic of China.

1 Liver-protective drugs, Part 37. This paper also forms Part 128 in the series on the validity of Oriental medicines.

Further Information

Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

From the crude drug “rorotsū”, the fruits of Liquidambar formosana, which are used in Taiwan as a liver-protective drug, seven constituents were isolated. Three were new compounds and their structures were determined as shown in formulas 1,2, and 3 based on spectral and chemical evidence. Among the isolated constituents, beturonic acid revealed remarkable protective activity on chemically-induced cytotoxicity in primary cultured rat hepatocytes.