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Planta Med 1988; 54(6): 506-510
DOI: 10.1055/s-2006-962531
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© Georg Thieme Verlag Stuttgart · New York

Tigliane-Type Diterpene Esters from Synadenium grantii 1,5

R. Bagavathi2 , B. Sorg3 , E. Hecker3
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  • 3German Cancer Research Center, Institute of Biochemistry, Im Neuenheimer Feld 280, D-6900 Heidelberg, Federal Republic of Germany.
1 Part XIV in the series ‘Skin Irritant Principles of Euphorbiaceae’, for part XIII see: Ref.(1).5 Dedicated to Prof. Dr. H. Schildknecht, Institute of Organic Chemistry, University of Heidelberg on occasion of his 65th birthday in appreciation of his many fascinating contributions to natural product chemistry.
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1987

Publikationsdatum:
24. Januar 2007 (online)

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Abstract

From the latex of Synadenium grantii Hook F. (Euphorbiaceae) were isolated by chromatographic methods five diterpene 12,13-diesters of the tigliane-type parent alcohols 4-deoxyphorbol (1a), 4,20-dideoxy-5α-hydroxyphorbol (2a) and 20-deoxy-5α-hydroxyphorbol (3a) with isobutyric, tiglic and phenylacetic acid. Of these, 4-deoxyphorbol-13-(phenylacetate)-12-tiglate (1f) turned out to be highly irritant on the mouse ear while the rest of the esters had rather low or no irritant activity; 1f was also assayed for tumor-promoting activity and proved to be almost inactive.