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Planta Med 1988; 54(6): 538-542
DOI: 10.1055/s-2006-962542
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© Georg Thieme Verlag Stuttgart · New York

Isobyakangelicin Angelate; A Novel Furanocoumarin from Peucedanum palustre

H. Vuorela1 , C. A. J. Erdelmeier2 , Sz. Nyiredy2 , K. Dallenbach-Tölke2 , C. Anklin3 , R. Hiltunen1 , O. Sticher2
  • 1Division of Pharmacognosy, School of Pharmacy, University of Helsinki, SF-00170 Helsinki, Finland.
  • 2Pharmazeutisches Institut, Eidgenössische Technische Hochschule Zürich, CH-8092 Zürich, Switzerland.
  • 3Bruker Spectrospin AG, CH-8117 Fällanden, Switzerland.
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Publication History

1988

Publication Date:
24 January 2007 (online)

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Abstract

Isobyakangelicin angelate, a new furanocoumarin and the five known coumarins, columbianadin, (+)-oxypeucedanin, (±)-oxypeucedanin hydrate, ostruthol, and isoimperatorin, were isolated from roots of Peucedanum palustre (L.) Moench using medium-pressure liquid chromatography [MPLC] with normal phase and subsequently with reversed phase as stationary phases. The mobile phases were optimized in TLC and HPLC preassays according to the “PRISMA” system and then transferred without modification to preparative MPLC separations. The structures of the compounds were elucidated by a combination of spectroscopic methods, among others the rotating frame Overhauser enhancement spectroscopy [ROESY] experiment.