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Planta Med 1987; 53(1): 12-15
DOI: 10.1055/s-2006-962606
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© Georg Thieme Verlag Stuttgart · New York

Inhibition of Angiotensin I Converting Enzyme by Flavanolic Compounds: In Vitro and In Vivo Studies

Marie-Thérèse Meunier1 , Françoise Villié1 , Madeleine Jonadet2 , Janine Bastide1 , Pierre Bastide1
  • 1Laboratoire de Chimie Biologique et de Pharmacodynamie, Faculté de Pharmacie, 28 place Henri Dunant, F-63001 Clermont-Ferrand, France.
  • 2CNRS, Faculté de Pharmacie, F-63001 Clermont-Ferrand, France.
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Publication History

1986

Publication Date:
24 January 2007 (online)

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Abstract

The procyanidolic oligomers coming from Vitis vinifera L. (two fractions) and Cupressus sempervirens L. (three fractions), and the monomers, (+)-catechin, (-)-epicatechin were tested for their effects on angiotensin I converting enzyme (ACE) activity. The oligomers are the most active (dose I50 of 0.08 mg/ml for the fraction A of Vitis, the most active substance). Monomers have little activity. In vivo, the vasopressive response to Ang I is inhibited by approximately 20% to 40% in the rabbit after administration of procyanidolic oligomers (5 mg/kg i. v.). Ang II also is inhibited which suggests another action, perhaps due to the forming of compounds between Ang I and II and the oligomers.