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Planta Med 1987; 53(1): 22-27
DOI: 10.1055/s-2006-962609
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© Georg Thieme Verlag Stuttgart · New York

Effect of Benzo[c]phenanthridine Alkaloids on Reverse Transcriptase and Their Binding Property to Nucleic Acids

Nobuko Kakiuchi1 , Masao Hattori1 , Hisashi Ishii2 , Tsuneo Namba1
  • 1Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-01 Japan.
  • 2Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoicho, Chiba, 260 Japan.
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Publikationsverlauf

1986

Publikationsdatum:
24. Januar 2007 (online)

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Abstract

Twelve benzo[c]phenanthridine alkaloids, naturally occurring and synthetic model compounds, were examined for their anti-reverse transcriptase activity. Significant inhibitory effects on AMV reverse transcriptase were found with avicine and 6-methylnitidine as well as with nitidine and fagaronine, whose inhibitory effects on this enzyme have been reported by Sethi et al. In the CD spectra, the mixtures of these four alkaloids with either (rA)n · (dT)12-18 or (rA)n · (dT)n showed induced CD bands at longer wavelengths, suggesting that they interacted with the nucleic acids.