Die Cardenolid-Glykoside der Blätter von Digitalis cariensis

Abstract

From the leaves of Digitalis cariensis in addition to the known glycosides, three new cardenolides, a major and two minor ones, have been isolated and their structures established as gluco-gitoxigenine-glucomethyloside (gitoxigenine-3-O-β-D-glucosyl-β-D-glucomethyloside), gitoxigenine-3-O-β-D-glucosyl-β-D-glucomethylosyl-β-D-bisdigitoxoside, and gitoxigenine-3-O-β-D-glucosyl-β-D-glucomethylosyl-β-D-digitoxide, respectively, by chemical evidence and FAB-MS. Except for the unstable glucolanadoxine, the known major components isolated from the leaves are glucogitoroside, glucoevatromonoside, digitalinum verum, gluco-digitoxigenine-glucomethyloside, glucodigifucoside, and glucogitofucoside. A total of 23 cardenolides present in the leaves in trace amounts were also identified.