Effect of Extract from Rhei Rhizoma on Dietary Hyperazotemia in Rats

Takako Yokozawa; Shuji Miyakawa; Maomi Suzuki; Hikokichi Oura; Ko Kaneko; Itsuo Nishioka

doi:10.1055/s-2006-962652

Planta Medica, Table of Contents

Planta Med 1987; 53(2): 124-127
DOI: 10.1055/s-2006-962652

Full Papers

Effect of Extract from Rhei Rhizoma on Dietary Hyperazotemia in Rats

Takako Yokozawa¹ , Shuji Miyakawa² , Maomi Suzuki¹ , Hikokichi Oura¹ , Ko Kaneko² , Itsuo Nishioka³

¹Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930-01, Japan.
²Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060, Japan.
³Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812, Japan.

Abstract

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Abstract

Although rats fed on a high protein diet of 70% casein showed hyperazotemia, administration of the extract from Rhei rhizoma showed decreases of blood urea nitrogen, ammonia nitrogen in the portal vein, urea concentration in hepatic tissue, Gln, Lys, Thr, Ala, Gly, Ser, Glu, Pro, Arg, Tyr, Cit, Asp, etc. in serum, while significant increases of Glu and Asp in hepatic tissue were observed. The mechanism of the blood urea nitrogen-decreasing activity of rhubarb extract is discussed on the basis of the present results.

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