Active Principles of Tetradenia riparia; II. Antispasmodic Activity of 8(14), 15-Sandaracopimaradiene-7α, 18-diol

Luc Van Puyvelde; Romain Lefebvre; Pierre Mugabo; Norbert De Kimpe; Niceas Schamp

doi:10.1055/s-2006-962660

Planta Medica, Inhaltsverzeichnis

Planta Med 1987; 53(2): 156-158
DOI: 10.1055/s-2006-962660

Full Papers

Active Principles of Tetradenia riparia; II. Antispasmodic Activity of 8(14), 15-Sandaracopimaradiene-7α, 18-diol

Luc Van Puyvelde¹ , Romain Lefebvre² , Pierre Mugabo² , Norbert De Kimpe³ , Niceas Schamp³

¹Centre Universitaire de Recherche sur la Pharmacopée et la Médecine Traditionnelle [CURPHAMETRA], Université Nationale du Rwanda, B.P.117, Butare, Rwanda.
²Heymans Institute, Faculty of Medecine, State University of Gent, B-9000 Gent, Belgium.
³Laboratory of Organic Chemistry, Faculty of Agricultural Sciences, State University of Gent, Coupure Links 653, B-9000 Gent, Belgium.

Abstract

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Abstract

Tetradenia riparia is one of the most popular medicinal plants in Rwanda. Previously, several new substances have been isolated from the leaves, including a new diterpenediol, i.e. 8(14),15-sandaracopimaradiene-7α,18-diol. This new diterpenediol exhibits a papaverine-like antispasmodic activity on the contractions of the guinea pig ileum provoked by methacholine, histamine, and barium chloride and on the noradrenaline-induced contractions of the rabbit aorta.

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