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Planta Med 1987; 53(6): 515-517
DOI: 10.1055/s-2006-962798
DOI: 10.1055/s-2006-962798
Full Papers
© Georg Thieme Verlag Stuttgart · New York
Inhibition of Mushroom-Tyrosinase by Aloe Extract
Further Information
Publication History
1986
Publication Date:
24 January 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/198706/lookinside/thumbnails/10.1055-s-2006-962798-1.jpg)
Abstract
Inhibition by Aloe extracts of L-dopa oxidation by mushroom-tyrosinase was examined. 2″-O-Feruloylaloesin and aloesin at concentrations of 0.4 µM showed inhibition of 27 and 30%, respectively. Lineweaver-Burk plots of the concentration of L-dopa in the absence and presence of 2″-O-feruloylaloesin, 0.4 and 0.8 µM, showed that this compound inhibits mushroom-tyrosinase noncompetitively. The Ki value obtained was 8.5 × 10-5 M. 2″-O-Feruloylaloesin and aloesin contents were analyzed by a reversed-phase HPLC, and their seasonal variations were observed.