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Planta Med 1987; 53(6): 521-525
DOI: 10.1055/s-2006-962800
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© Georg Thieme Verlag Stuttgart · New York

Effects of an Active Substance Isolated from the Roots of Angelica shkiokiana on Leukotriene and Monohydroxyeicosatetreaenoic Acid Biosyntheses in Human Polymorphonuclear Leukocytes

Yoshiyuki Kimura1 , Hiromichi Okuda1 , Kimiye Baba2 , Mitsugi Kozawa2 , Shigeru Arichi3
  • 12nd Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu-cho, Onsen-gun, Ehime 791-02, Japan.
  • 2Osaka University of Pharmaceutical Sciences, Kawai 2-10-65, Matsubara, Osaka 580, Japan.
  • 3The Research Institute of Oriental Medicine, Kinki University, Sayama-cho, Minamikawachi-gun, Osaka 589, Japan.
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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

It was found that the EtOAc fraction of the roots of Angelica shkiokiana Makino inhibited calcium ionophore-induced LTB4 and LTC4 formations in human polymorphonuclear leukocytes (PMN-L). And the active substance isolated from this root of was elucidated to be 3′ (R), 4′ (R)-3′-epoxyangeloyloxy-4′-acetoxy-3′, 4′-dihydroseselin (YN-1). Furthermore, YN-I at concentrations of 4-400 µg/ml inhibited calcium ionophore-induced 12-HETE, 5-HETE, LTB4, and LTC4 formation in human PMN-L, dose-dependently, as shown by measurements with reversed phase HPLC and radioimmunoassay systems.